End Point Assessment in Gliomas: Novel Treatments Limit Usefulness of Classical Macdonald's Criteria

End point assessment in gliomas: novel treatments limit usefulness of classical Macdonald's Criteria.

Recent trials in glioma have revealed significant limitations in the end points used. This requires a critical and comprehensive review of how brain tumor trials are conducted, particularly of which end points are defined and how response and progression are defined.

18F-FDG PET/CT usefulness vs Tc99m-Tetrofosmin in the assessment of malignant brain gliomas: Report of two cases

Gliomas account for almost 80% of primary malignant brain tumors in adults. Magnetic Resonance imaging (MRI) is still the gold standard for diagnosis of brain tumors and brain 99mTc-tetrofosmin Single Photon Emission Computed Tomography (99mTc-tetrofosmin-SPECT) has been established as a useful tool for their evaluation. Fluorine-18–2-fluoro-2-deoxy-d-glucose positron emi...

18f-fdg pet/ct usefulness vs tc99m-tetrofosmin in the assessment of malignant brain gliomas: report of two cases

gliomas account for almost 80% of primary malignant brain tumors in adults. magnetic resonance imaging (mri) is still the gold standard for diagnosis of brain tumors and brain 99mtc-tetrofosmin single photon emission computed tomography (99mtc-tetrofosmin-spect) has been established as a useful tool for their evaluation. fluorine-18–2-fluoro-2-deoxy-d-glucose positron emission tomography/comput...

Updated response assessment criteria for high-grade gliomas: response assessment in neuro-oncology working group.

Currently, the most widely used criteria for assessing response to therapy in high-grade gliomas are based on two-dimensional tumor measurements on computed tomography (CT) or magnetic resonance imaging (MRI), in conjunction with clinical assessment and corticosteroid dose (the Macdonald Criteria). It is increasingly apparent that there are significant limitations to these criteria, which only ...

Limit Circle/Limit Point Criteria for Second-Order Superlinear Differential Equations with a Damping Term